BENG504 Advanced Molecular Biology
Advanced Molecular Biology is an advanced course on the molecular biology of pro- and eukaryotic organisms. Topics include chromosome structure and organization, RNA transcription, selected aspects of the molecular regulation of gene expression, protein synthesis and post-translational regulation, DNA synthesis, repair, and recombination.
BENG505 Current Topics in Molecular Biology
Current Topics in Molecular Biology is an advanced course on recent developments of molecular biology and its translational aspects.
The course covers computational techniques for mining large amount of information produced by recent advances in biology, including genome sequencing and microarrray technologies. The main topics of the course include DNA and protein sequence alignment, sequence motifs/patterns, phylogenetic trees, protein structures, microarray data analysis and biological networks.
BENG507 Human Molecular Genetics
Advanced molecular biology is an advanced course on the molecular biology of pro- and eukaryotic organisms. Topics include chromosome structure and organization, RNA transcription, selected aspects of the molecular regulation of gene expression, protein synthesis and post-translational regulation, DNA synthesis, repair and recombination.
BENG508 Advanced Cell Biology
Advanced Cell Biology course deals with the biology of cells of higher organisms: The structure, function, and biosynthesis of cellular membranes and organelles; cell growth and oncogenic transformation; transport, receptors, and cell signaling; the cytoskeleton, the extracellular matrix, and cell movements; chromatin structure and RNA synthesis.
BENG510 Advanced Biochemistry
This course will review the chemistry of living systems, with an emphasis on topics of biotechnological and biomedical interest. The course will also survey the methods used in modern biochemistry, so that students will be able to understand the connection between empirical data and the established facts and concepts presented in the course. The first part of the course will focus on the relationship between structure and function of proteins, nucleic acids, carbohydrates, lipids, and membranes. Important chemical concepts relevant to these molecules and their components (amino acids, nucleotides, etc.), such as pH and weak chemical interactions, will be presented. After an introduction to enzyme kinetics, the course will concentrate on the principles and pathways of intermediary metabolism. The final topics will be concerned with informational biochemistry – DNA replication, recombination, repair, and transcription, as well as protein synthesis.
BENG512 Biotechnology and Biosafety
Modern Biotechnological approach. Historical development of biotechnology and biosafety. Transgenic applications. Biosafety of transgenic applications. Assessment methods to evaluate the effects of genetically changed organisms for food safety and environment. Biosafety systems. Biotechnological applications. Comparison of specific similarity and precaution principle approaches. Effect of biotechnological applications to human health and biological variation. Biosafety control systems. Risk assessment and risk management for biosafety systems. Internatiomal biosafety protocols and rules in different countries. Socioeconomical and ethical issues in Biotechnology.
BENG514 Cancer Biology and Treatment
Provides an integrated lecture series summarizing current knowledge in cancer biology and integrating current literature with basic concepts. Topics include molecular mechanisms of cancer initiation, progression and metastasis, signal transduction, types of cancer, pathology, sources of carcinogens, genetic and epigenetic mechanisms and consequences, therapeutic resistance, cancer markers and therapeutic targets, statistics of incidence/survival, Students will learn to use online databases to develop independent strategies for analyzing datasets. There will be several writing assignments and in class oral presentations of research articles.
BENG515 Introduction to Tissue Engineering
Description of tissue engineering. Fundamentals; importance of cell-scaffold-biosignal molecule integration. Scaffold characteristics, general design criteria will be covered. Selection of cell sources and stem cells, in vitro culture conditions, and tissue engineered products and problems in their clinical utilization will be discussed. Organ tissue engineering.
BENG517 Polymeric Biomaterials
Basics of polymer structure. Classification of polymers by source, chemistry, shape, end-use, etc. Natural and synthetic polymers. Criteria of polymer type selection. Types of natural polymers, structures, isolation-purification, applications (chitosan, alginate, cellulose, collagen, starch, gelatin); types of synthetic polymers, synthesis-purification, applications (biodegradable polymers, silicones, PET, PTFE, PU, polyamides, acrylate-based polymers). Applications of biomedical polymers; dental, orthopedical applications, adhesives, sutures, vascular grafts, wound dressings, controlled release materials, carriers for drug/gene delivery.
Description and history of biomaterials. Criteria for the success of a biomaterial. Biocompatibility definition. Classification and general application types will be discussed. Biomaterials surface characteristics, investigation techniques: FTIR-ATR, SEM, surface tension, ESCA, etc. Mechanical properties and measurement, optical and diffusion properties. Material types, advantages and disadvantages: metals, ceramics, composites, polymers. Material fabrication techniques. Material- tissue interaction; coagulation, immune response, foreign body reaction. Discussion of a biomaterial journey: from lab to body.
BENG521 Biomedical Electronics
Introduction of biomedical system. Principle and design of various biomedical devices such as pacemaker, EEG, ECG, EMG, ve ICU equipment, diagnostic imaging devices, blood bank monitor, CT, MRI, mammography, ultrasound, endoscope, confocal microscope, multiphoton flourescent microscope.
BENG524 Materials Design and Fabrication for Tissue Engineering
Description of a tissue engineering scaffold; characteristics of an ideal scaffold. Cells, scaffold, biosignal molecules relationship. Design criteria of a scaffold; material selection. Methods for scaffold fabrication: salt leaching, ice-particle leaching, gas-foaming, particle aggregation, freeze drying, thermally induced phase separation, centrifugation, supercritical carbon dioxide, fiber production, electrospinning, solid freeform fabrication, 3D printing. Bioplotter. nanopatterning, microcontact printing.